TIM3 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | TIM3 |
| Clone | BLR033F |
| Host Species | Recombinant Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 10 µl (5+ tests) |
| Concentration | 1000 µg/ml |
| Applications | WB, IHC, ICC, IHC-IF, Flow Cyt |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-TIM3 recombinant monoclonal antibody [BLR033F]. TIM3 (HAVCR2) is a cell surface receptor implicated in modulating innate and adaptive immune responses. It is generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. TIM3 regulates macrophage activation, inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses, and promotes immunological tolerance. In CD8+ cells TIM3 attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8TDQ0]. |
| Immunogen | Residues 22-201 (ECD) |
| Other Names | T-cell membrane protein 3; TIMD-3; TIMD3; TIM3; T-cell immunoglobulin mucin receptor 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin and mucin domain-containing protein 3; KIM-3; kidney injury molecule-3; hepatitis A virus cellular receptor 2; HAVcr-2; CD366; CD antigen CD366; T cell immunoglobulin mucin 3; Tim-3 |
| Gene, Accession # | Accession: NP_116171.3, Gene ID: 84868, UniProt: Q8TDQ0 |
| Catalog # | A700-033-T |
| Price | $127 |
| Order / More Info | TIM3 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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