CSK Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | CSK |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted: mouse, rat, chicken, bovine) |
| Isotype | n/a |
| Format | affinity purified |
| Size | 100 µl |
| Concentration | 1000 µg/ml |
| Applications | IP |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-CSK antibody, affinity purified. C-Src kinase (CSK) is a non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. CSK suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P41240]. |
| Immunogen | Between 400 and C-terminus |
| Other Names | CSK, non-receptor tyrosine kinase; tyrosine-protein kinase CSK; protein-tyrosine kinase CYL; C-Src kinase; c-src tyrosine kinase |
| Gene, Accession # | Accession: NP_004374.1, Gene ID: 1445, UniProt: P41240 |
| Catalog # | A304-230A |
| Price | $433 |
| Order / More Info | CSK Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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