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Antigenic Specificity | RPA70 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse (predicted: rabbit, orangutan, monkey, gorilla, chimpanzee, tasmanian devil, white-tuft |
Isotype | n/a |
Format | affinity purified |
Size | 100 µl |
Concentration | 250 µg/ml |
Applications | IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-RPA70 IHC antibody, affinity purified. Replication protein A (RPA) is a multisubunit complex that carries out DNA mismatch repair (MMR) in association with MSH2 (a subunit of human MutS heterodimers), MLH1 (a subunit of human MutL heterodimers), PCNA, and DNA polymerase-delta. RPA is composed of a heterotrimer that includes subunits of 70 kDa (RPA1), 32kDa (RPA2), and 14kDa (RPA3). RPA1, the 70 kDa subunit, is an ssDNA binding protein that has been shown to be phosphorylated by ATM and ATR in response to DNA damage. In addition to a role in MMR, RPA also functions in the initiation of DNA replication and DNA unwinding at origins of replication. |
Immunogen | Between 350 and 400 |
Other Names | RP-A; single-stranded DNA-binding protein; replication protein A1, 70kDa; RP-A p70; RF-A protein 1; RF-A; replication factor A protein 1; REPA1; replication protein A 70 kDa DNA-binding subunit; MSTP075; MST075; HSSB; RPA70 |
Gene, Accession # | Accession: NP_002936.1, Gene ID: 6117, UniProt: P27694 |
Catalog # | IHC-00409 |
Price | $459 |
Order / More Info | RPA70 Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |