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Antigenic Specificity | RRP8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 10 µl |
Concentration | 1000 µg/ml |
Applications | IP |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-RRP8 antibody, affinity purified. Ribosomal RNA-processing protein (RRP8) is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43159]. |
Immunogen | Between 406 and C-terminus |
Other Names | nucleomethylin; RRP8 methyltransferase homolog; cerebral protein 1; ribosomal RNA processing 8, methyltransferase, homolog; NML; KIAA0409; ribosomal RNA-processing protein 8 |
Gene, Accession # | Accession: NP_056139.1, Gene ID: 23378, UniProt: O43159 |
Catalog # | A304-202A-T |
Price | $121 |
Order / More Info | RRP8 Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |