TRAF6 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | TRAF6 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 10 µl |
| Concentration | 1000 µg/ml |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-TRAF6 antibody, affinity purified. TNF receptor-associated factor 6 (TRAF6) is an E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. TRAF6 also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. TRAF6 leads to the activation of NF-kappa-B and JUN. TRAF6 may be essential for the formation of functional osteoclasts, and it regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. TRAF6 also seems to play a role in dendritic cells (DCs) maturation and/or activation. TRAF6 represses c-Myb-mediated transactivation, in B-lymphocytes. TRAF6 is an adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y4K3]. |
| Immunogen | Between 472 and C-terminus |
| Other Names | TNF receptor-associated factor 6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase; RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; MGC:3310; interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6 |
| Gene, Accession # | Accession: NP_004611.1, Gene ID: 7189, UniProt: Q9Y4K3 |
| Catalog # | A303-803A-T |
| Price | $121 |
| Order / More Info | TRAF6 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
FORTIS LIFE SCIENCES
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