Allergin-1, Mouse Antibody from HYCULT BIOTECH
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| Antigenic Specificity | Allergin-1, Mouse |
| Clone | TX83 |
| Host Species | Mouse |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 20 µg |
| Concentration | n/a |
| Applications | Flow cytometry. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Monoclonal antibody clone Tx83 recognizes mouse allergy inhibitory receptor-1 (Allergin-1; also known as mast cell antigen AG-32). It is an immune regulatory molecule predominantly expressed on mast cells, but also found on other myeloid cells like macrophages, dendritic cells and neutrophils. The receptor consist of an immunoreceptor tyrosine-based inhibitory motif (ITIM) like domain. It's main function is to suppress IgE (FcεRI-) mediated degradation and TLR2- mediated signaling in mast cells. Thereby inhibiting production of cytokines and other inflammatory mediators. Allergin-1 is tyrosine phosphorylated and recruits SH2 phosphatases , such as SHP-1, SHP-2 or SHIP. Co-ligation with FcεRI decreases mast cell degranulation. Currently three isoforms of human allergin-1 are identified: allergin-1L, Allergin-1S1 & allergin-1S2. Mast cells play a pivotal role in allergic reactions in barrier tissues, like skin and intestinal mucosa. Allergin-1 is suggested to play a role in skin diseases like dermatitis, the autoimmune diseases such as SLE and airway hyperresponsiveness. In macrophages it is suggested to play a role by suppressing autoantibody production via the promotion of apoptotic cell clearance. |
| Immunogen | TX83 was generated by immunizing Allergin-1-deficient mice with BW5147 transfectants expressing Flag-tagged Allergin-1. |
| Other Names | allergy inhibitory receptor-1 , mast cell antigen AG-32 |
| Gene, Accession # | n/a |
| Catalog # | HM1143-20UG |
| Price | $157 |
| Order / More Info | Allergin-1, Mouse Antibody from HYCULT BIOTECH |
| Product Specific References | n/a |
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353
info@hycultbiotech.com
https://www.hycultbiotech.com
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