Human CCR5 Antibody from ICHORBIO
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| Antigenic Specificity | Human CCR5 |
| Clone | HEK/1/85a/7a |
| Host Species | Rat |
| Reactive Species | human |
| Isotype | IgG2b kappa |
| Format | Protein A/G purified, low endotoxin |
| Size | 25mg |
| Concentration | ≥ 5.0 mg/ml |
| Applications | Flow Cytometry, ImmunoCytochemistry. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Clone HEK/1/85a/7a recognizes an epitope on human CCR5. CCR5 antibody, HEK/1/85a/7a, recognizes C-C chemokine receptor type 5 (CCR5), also known as CD195, CC-CKR-5, CHEMR13, and HIV-1 fusion coreceptor. CCR5 is a 45 kDa seven-transmembrane G-protein-coupled receptor (GPCR). CCR5 is expressed on a subset of memory T cells, macrophages, and immature dendritic cells (DCs) and is upregulated by proinflammatory cytokines. CCR5 binds to inflammatory CC-chemokines, including CCL3 (macrophage inflammatory protein (MIP)-1α), CCL4 (MIP-1β), and RANTES, which increases intracellular calcium levels and results in cytoskeletal rearrangement and chemotactic cell migration. CCR5 is also the coreceptor for HIV-1 following binding of viral gp120 to CD44-7. The levels of CCR5 on cells influence the rate of entry of HIV-1, and patients with lower levels of CCR5 exhibit immunity against infection. CCR5 also contributes to other human diseases, including type I diabetes and cancer. |
| Immunogen | CHO cells transfected with full-length human CD195 (CCR5). |
| Other Names | C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, HIV-1 fusion coreceptor, CD195 |
| Gene, Accession # | UniProt: P51681 |
| Catalog # | ICH1172-25mg |
| Price | $1100 |
| Order / More Info | Human CCR5 Antibody from ICHORBIO |
| Product Specific References | n/a |
ICHORBIO
ICHORBIO
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Wantage OX12 9FF ENGLAND
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Wayne, PA 19087
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