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Antigenic Specificity | Human CD119 |
Clone | GIR 208 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | Protein A/G purified, low endotoxin |
Size | 100mg |
Concentration | 1.0 - 5.0 mg/ml |
Applications | Immunoprecipitation, Western Blot, ELISA, Neutralization, Flow Cytometry. RUO |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Anti-CD119 In Vivo Antibody - Low Endotoxin (GIR 208) recognizes Human IFN gamma R alpha. Interferon-gamma (IFN-gamma) exerts its biologic effects by interacting with a single high affinity receptor, IFN-gamma receptor. This receptor is present on almost all cell types except mature erythrocytes. The IFN-gamma receptor consists of two polypeptide chains alpha and beta and requires association of JAK1, JAK2 and Stat1 for IFN-gamma signal transduction. In signal transduction, IFN-gamma induces tyrosine phosphorylation of IFN-gamma receptor alpha (IFNGR1) leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-gamma induced gene transcription. The IFN-gamma receptor is structurally related to the recently cloned IL-10 receptor. GIR 208 binds IFNGR1 and blocks binding of IFN-gamma to the receptor. |
Immunogen | Human IFN-gamma R alpha, Purified from human placenta |
Other Names | Interferon gamma receptor 1, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, Interferon gamma receptor alpha-chain2, IFN-gamma-R-alpha |
Gene, Accession # | UniProt: P15260 |
Catalog # | ICH1028-100mg |
Price | $2600 |
Order / More Info | Human CD119 Antibody from ICHORBIO |
Product Specific References | n/a |
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