PSA-NCAM, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | PSA-NCAM, Human/Mouse/Rat |
| Clone | 2-2B |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgM |
| Format | purified |
| Size | 100 µg in 1 mL |
| Concentration | n/a |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PSA-NCAM Antibody, anti-human/mouse/rat, pure. The Anti-PSA-NCAM antibody recognizes an epitope on human, mouse, and rat polysialic acid (PSA) which, in vertebrates, is found linked to the extracellular domain of the neural cell adhesion molecule (NCAM, CD56). PSA-NCAM, the highly polysialated form of NCAM, is predominantly expressed in embryonic and neonatal neural tissue. In adult mammalian brain PSA-NCAM expression is restricted mainly to areas that retain neurogenic potential, such as the subventricular zone (SVZ) and the dentate gyrus of the hippocampus. PSA-NCAM is a marker for immature neuronal-committed progenitors that are permanently generated in the SVZ and migrate along a well-defined pathway, the rostral migratory stream, into the olfactory bulb where they differentiate into GABAergic and dopaminergic interneurons. Antibodies against PSA-NCAM have also been used to immunomagnetically isolate neuronal progenitors from postnatal mice and rat forebrain. |
| Immunogen | n/a |
| Other Names | NCAM1, CD56, MSK39, NCAM, E-NCAM, NCAM-1, NCAM-C |
| Gene, Accession # | n/a |
| Catalog # | 130-115-809 |
| Price | $495 |
| Order / More Info | PSA-NCAM, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Jungblut, M. et al. (2012) Isolation and characterization of living primary astroglial cells using the new GLAST-specific monoclonal antibody ACSA-1. Glia 60 (6): 894-907. | G. Kantzer, C. et al. (2017) Anti-ACSA-2 defines a novel monoclonal antibody for prospective isolation of living neonatal and adult astrocytes. Glia 65 (6): 990-1004. | Batiuk, M. Y. et al. (2017) An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody. J. Biol. Chem. 292 (21): 8874-8891. | Rougon, G. and Marshak, D. R. (1986) Structural and immunological characterization of the amino-terminal domain of mammalian neural cell adhesion molecules. J. Biol. Chem. 261: 3396-3401. | Doetsch, F. et al. (1997) Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J. Neurosci. 17: 5046-5061. | Marmur, R. et al. (1998) Differentiation of oligodendroglial progenitors derived from cortical multipotent cells requires extrinsic signals including activation of gp130/LIFbeta receptors. J. Neurosci. 18: 9800-9811. | Seki, T. (2002) Expression patterns of immature neuronal markers PSA-NCAM, CRMP-4 and NeuroD in the hippocampus of young adult and aged rodents. J. Neurosci. Res. 70: 327-334. | Pennartz, S. et al. (2004) Purification of neuronal precursors from the adult mouse brain: comprehensive gene expression analysis provides new insights into the control of cell migration, differentiation, and homeostasis. Mol. Cell. Neurosci. 25: 692-706. | Seidenfaden, R. et al. (2006) Glial conversion of SVZ-derived committed neuronal precursors after ectopic grafting into the adult brain. Mol. Cell. Neurosci. 32: 187-198. | Metsuyanim, S. et al. (2009) Expression of stem cell markers in the human fetal kidney. PLoS One 4 (68): e6709. | Kiss, J. Z. and Muller, D. (2001) Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity. Rev. Neurosci. 12: 297-310. | Seidenfaden et al. (2006) MACS&more 10 (1): 4-6. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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