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Antigenic Specificity | MSCA-1, Human |
Clone | REA781 |
Host Species | Recombinant Human |
Reactive Species | human, nonhuman primate, other |
Isotype | IgG1 |
Format | allophycocyanin (APC) conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MSCA-1 Antibody, anti-human, APC, REAfinity™. Clone REA781 recognizes the human mesenchymal stromal cell antigen-1 (MSCA-1) antigen, a GPI-anchored protein also known as tissue non-specific alkaline phosphatase (TNAP). MSCA-1 was shown to be restricted to mesenchymal stromal cells (MSCs) in the CD271bright population in bone marrow. These CD271brightCD45dim MSCs have a much higher clonogenic capacity compared to the CD271+CD45+ fraction in bone marrow. Therefore, MSCA-1 is a suitable marker to identify MSCs with a high proliferative potential. | Additional information: Clone REA781 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP |
Gene, Accession # | Gene ID: 249 |
Catalog # | 130-111-350 |
Price | $325 |
Order / More Info | MSCA-1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Battula, V. L. et al. (2007) Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation 75: 279-291. | Buhring, H. J. et al. (2007) Novel markers for the prospective isolation of human MSC. Ann. N. Y. Acad. Sci. 1106: 262-271. | Rozemuller, H. et al. (2010) Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies. Stem Cells Dev. 19: 1911-1921. | Sobiesiak, M. et al. (2010) The mesenchymal stem cell antigen MSCA-1 is identical to tissue non-specific alkaline phosphatase. Stem Cells Dev. 19: 669-677. |