IL-17F, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | IL-17F, Human |
| Clone | REA1012 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio B515 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IL-17F Antibody, anti-human, Vio® B515, REAfinity™. Clone REA1012 recognizes the human interleukin 17F (IL-17F) antigen, a homodimeric, 34 kDa member of the IL-17 family, which includes IL-17A, IL-17B, IL-17C, IL-17D, and IL-17E (also called IL-25). Interleukin 17 functions as a proinflammatory cytokine that responds to the invasion of the immune system by extracellular pathogens and induces destruction of the pathogen's cellular matrix. Phylogenetic analysis reveals that among IL-17 family members, the IL-17F isoforms 1 and 2 (ML-1) have the highest homology to IL-17A (sharing 55 and 40% amino acid identity to IL-17A). IL-17F has been shown to have a pro-inflammatory role in asthma. It is expressed in the airway of asthmatics and its expression level is correlated with disease severity. IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. It is derived from several cell types such as T helper 17 (T?17) cells, mast cells and basophils, and shows a wide tissue expression pattern including lung. Overexpression of the IL-17F gene in the airway of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. Hence, IL-17F may have a crucial role in allergic airway inflammation, and have important therapeutic implications in asthma. | Additional information: Clone REA1012 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Interleukin-17F, CANDF6, ML-1 |
| Gene, Accession # | Gene ID: 112744 |
| Catalog # | 130-130-651 |
| Price | $382 |
| Order / More Info | IL-17F, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Starnes, T. et al. (2001) Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol 167 (8): 4137-4140. | Yang, X. O. et al. (2008) Regulation of inflammatory responses by IL-17F. J. Exp. Med. 205 (5): 1063-1075. | Kawaguchi, M. et al. (2009) Role of interleukin-17F in asthma. Inflamm. Allergy Drug Targets 8 (5): 383-389. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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