CD310 (VEGFR-3), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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|---|---|
| Antigenic Specificity | CD310 (VEGFR-3), Human |
| Clone | REA419 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD310 (VEGFR-3) Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA419 recognizes the human CD310 antigen, a single-pass type I membrane protein also known as vascular endothelial growth factor receptor 3 (VEGFR-3) or Fms-like tyrosine kinase 4 (FLT-4). CD310 is a tyrosine-protein kinase that acts as a cell-surface receptor for the vascular endothelial growth factors VEGF-C and VEGF-D. It plays an essential role in adult lymph-angiogenesis, in the development of the vascular network, and the cardiovascular system during embryonic development. During early embryogenesis all endothelial cells express CD310, while in the adult tissues, CD310 expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. CD310 plays a major role in tumor growth and metastatic tumor cell dissemination. The receptor is over-expressed on lymphatic vessels in the vicinity of tumors and on the tumor vasculature and therefore may be an excellent target for an effective cancer intervention. | Additional information: Clone REA419 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | FLT-4, FLT41, LMPH1A, PCL, VEGFR3 |
| Gene, Accession # | Gene ID: 2324 |
| Catalog # | 130-106-582 |
| Price | $330 |
| Order / More Info | CD310 (VEGFR-3), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Achen, M. G. et al. (1998) Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc. Natl. Acad. Sci. U.S.A. 95 (2): 548-553. | Pajusola, K. et al. (1992) FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res. 52 (20): 5738-5743. | Tammela, T. et al. (2011) VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat. Cell Biol. 13 (10): 1202-1213. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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