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Antigenic Specificity | CD39, Human |
Clone | REA739 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | Vio Bright FITC conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD39 Antibody, anti-human, Vio® Bright FITC, REAfinity™. Clone REA739 recognizes the 70-100 kDa membrane-bound human CD39 molecule, which is expressed on an effector/memory-like subset of FoxP3+ regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. Together with CD73, which is an ecto-5'-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells. | Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells. | Additional information: Clone REA739 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80 |
Gene, Accession # | Gene ID: 953 |
Catalog # | 130-110-654 |
Price | $395 |
Order / More Info | CD39, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Maliszewski, C. R. et al. (1994) The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J Immunol 153 (8): 3574-3583. | Kaczmarek, E. et al. (1996) Identification and characterization of CD39/vascular ATP diphosphohydrolase. J. Biol. Chem. 271 (51): 33116-33122. | Borsellino, G. et al. (2007) Expression of ectonucleotidase CD39 by FoxP3+ reg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110: 1225-1232. |