Aiolos, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Aiolos, Mouse |
| Clone | REA655 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Aiolos Antibody, anti-mouse, APC, REAfinity™. Clone REA655 recognizes the mouse Aiolos antigen, a member of the Ikaros family of zinc finger transcription factors, also known as IKZF3. The expression is restricted to lymphoid tissues. Aiolos is highly expressed in spleen and mature B cells and at lower levels in thymus and bone marrow. It was first detected in more committed lymphoid progenitors and strongly up-regulated as these differentiate into pre-T and pre-B cell precursors. It is suggested, that the increase of Ikaros and Aiolos in differentiating lymphocytes is essential for normal progression to a mature and immunocompetent state. Aiolos interacts with Ikaros to regulate lymphocyte differentiation. | Additional information: Clone REA655 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | IKZF3, Zfpn1a3, Znfn1a3, 5830411O07Rik |
| Gene, Accession # | Gene ID: 22780 |
| Catalog # | 130-110-241 |
| Price | $89 |
| Order / More Info | Aiolos, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Wang, J. H. et al. (1998) Aiolos regulates B cell activation and maturation to effector state. Immunity 9 (4): 543-553. | Morgan, B. et al. (1997) Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16 (8): 2004-2013. | Huttlin, E. L. et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143 (7): 1174-1189. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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