Description | CD126 (IL-6Rα) Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA291 recognizes the CD126 antigen, a type I cytokine receptor also known as interleukin 6 receptor subunit alpha (IL-6Rα) or membrane glycoprotein 80 (gp80). CD126 associates with the IL-6 receptor β chain (CD130 or gp130) resulting in the formation of a functional high affinity IL-6 receptor (IL-6R) complex. It is also shared by many other receptors like leukemia inhibitory factor (LIF), ciliary neurotropic factor (CNTF), oncostatin M (OSM), IL-11, and cardiotropin 1 (CT-1). CD126 (IL-6Rα) is highly expressed on activated and EBV-transformed B cells, plasma cells, and myeloma cells. Lower expression levels are detected on T cells, monocytes, granulocytes, hepatocytes, epithelial cells, fibroblasts, and neural cells. Interleukin 6 (IL-6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. A soluble form of CD126 also exists in human serum. Dysregulated production of IL-6 and the IL-6R are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer. | Additional information: Clone REA291 displays negligible binding to Fc receptors. | |
Product Specific References | Yamasaki, K. et al. (1998) Cloning and expression of the human interleukin-6 (BSF-2/IFN β2) receptor. Science 241 (4867): 825-828. | Schooltink, H. et al. (1991) Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. Biochem. J. 277 (3): 659-664. | Taga, T. et al. (1989) Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58 (3): 573-581. | Schloder, J. et al. (2017) Dimethyl fumarate therapy significantly improves the responsiveness of T cells in Multiple sclerosis patients for immunoregulation by regulatory T cells. Int J Mol Sci 18: E271. |