Edit |   |
---|---|
Antigenic Specificity | ZAP70, Human |
Clone | REA814 |
Host Species | Recombinant Human |
Reactive Species | human, mouse |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | ZAP70 Antibody, anti-human, PE, REAfinity™. Clone REA814 recognizes the human zeta-chain-associated protein kinase 70 (ZAP70). ZAP70 plays an essential role in regulation of the adaptive immune response. It is normally expressed near the surface membrane of T cells and natural killer cells. Zap70 associates with the ζ subunit of the T cell antigen receptor and plays a critical role in T cell-signaling. It regulates both T cell-activation switch on and switch off by modulating TCR expression at the T cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection. Additionally, the ZAP70-dependent signaling pathway may also contribute to primary B cells formation and activation through the B cell receptor. Recruitment and activation of ZAP70 are transient and are terminated by phosphorylation of negative regulatory tyrosine residues and dephosphorylation of positively acting sites. | Additional information: Clone REA814 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | ZAP-70, SRK |
Gene, Accession # | Gene ID: 7535 |
Catalog # | 130-112-179 |
Price | $315 |
Order / More Info | ZAP70, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Chan, A. C. et al. (1992) ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 71 (4): 649-662. | Arpaia, E. et al. (1994) Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. Cell 76 (5): 947-958. |