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Antigenic Specificity | CD152, Mouse |
Clone | UC10-4B9 |
Host Species | Hamster |
Reactive Species | mouse |
Isotype | IgG1 |
Format | purified |
Size | 500 µg in 0.5 mL |
Concentration | n/a |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD152 Antibody, anti-mouse, pure-functional grade. The monoclonal antibody UC10-4B9 reacts with CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4), which is a 33 kDa member of the immunoglobin superfamily and is expressed on activated T cells at a low level. CTLA-4 and CD28 have similarities concerning B7 family counter-receptors. While CD28 delivers a costimulary signal in T cell activation, CD152 restricts the progression of T cells to an activated state by inhibiting interleukin 2 (IL-2) secretion and cellular proliferation. A large proportion of CTLA-4 is intracellular localized. For a complete detection it may be necessary to assess intracellular staining in addition to surface expression of CD152. |
Immunogen | n/a |
Other Names | CTLA4, CTLA-4, Ly-56 |
Gene, Accession # | Gene ID: 12477 |
Catalog # | 130-097-503 |
Price | $400 |
Order / More Info | CD152, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Walunas, T. L. et al. (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1 (5): 405-413. | Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182 (2): 459-465. | June, C. H. et al. (1994) The B7 and CD28 receptor families. Immunol. Today 15 (7): 321-331. |