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Antigenic Specificity | CD106 (VCAM-1), Mouse |
Clone | 429 (MVCAM.A) |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2aκ |
Format | phycoerythrin (PE) conjugate |
Size | 9 µg in 300 µL |
Concentration | 1:10 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD106 (VCAM-1) Antibody, anti-mouse, PE. Clone 429 (MVCAM.A) recognizes the mouse CD106 antigen, a 110 kDa single chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow stromal cells and inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal transduction. The interactions play a pathophysiologic role in leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation. |
Immunogen | n/a |
Other Names | VCAM1, INCAM-100 |
Gene, Accession # | Gene ID: 22329 |
Catalog # | 130-104-759 |
Price | $52 |
Order / More Info | CD106 (VCAM-1), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Kumar, A. G. et al. (1994) Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form J Immunol 153 (9): 4088-4098. | Kokovay, E. et al. (2012) VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression. Cell Stem Cell 11 (2): 220-230. | Ou, R. et al. (2008) Regulation of immune response and inflammatory reactions against viral infection by VCAM-1. J. Virol. 82 (6): 2952-2965. |