CD63, Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD63, Rat |
| Clone | REA444 |
| Host Species | Recombinant Human |
| Reactive Species | rat |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD63 Antibody, anti-rat, APC, REAfinity™. Clone REA444 recognizes the rat CD63 antigen, a multi-pass membrane protein which is also known as mast cell antigen AD1 or melanoma antigen ME491. CD63 is located on the basophilic granule membranes in resting basophils, mast cells, and platelets, and is also located on the plasma membranes of these cells. It is also found on rat embryonic fibroblasts and hepatic cell. CD63 belongs to the tetraspanin transmembrane 4 superfamily (TM4SF) of proteins, which are characterized by four membrane spanning domains. Tetraspanins, via various homotypic and heterotypic interactions, regulate the spatial location and trafficking of associated transmembrane partners, eventually regulating and co-ordinating various signaling pathways. CD63 functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. It promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading, and migration. | Additional information: Clone REA444 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | AD1, ME491 |
| Gene, Accession # | Gene ID: 29186 |
| Catalog # | 130-106-833 |
| Price | $66 |
| Order / More Info | CD63, Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Nishikata, H. et al. (1992) The rat mast cell antigen AD1 (homologue to human CD63 or melanoma antigen ME491) is expressed in other cells in culture. J Immunol 149 (3): 862-870. | Amano, T. et al. (2001) Dynamics of intracellular granules with CD63-GFP in rat basophilic leukemia cells. J. Biochem. 129 (5): 739-744. | Kitani, S. et al. (1991) A cell surface glycoprotein of rat basophilic leukemia cells close to the high affinity IgE receptor (Fc epsilon RI). Similarity to human melanoma differentiation antigen ME491. J. Biol. Chem. 266 (3): 1903-1909. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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