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Antigenic Specificity | CD42b, Human |
Clone | REA185 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | biotin conjugate |
Size | 30 tests in 300 µL |
Concentration | 1:11 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD42b Antibody, anti-human, Biotin, REAfinity™. Clone REA185 recognizes CD42b, a 145 kDa single-pass type I membrane protein. Expression of CD42b is found on platelets and megakaryocytes. CD42b, the α chain, together with the β chain (CD42c), forms the heterodimer, glycoprotein Ib (GP Ib). The GP Ib receptor complex further includes association of the α and β subunits with platelet glycoprotein IX and glycoprotein V and this complex serves as the receptor for von Willebrand factor (VWF). The interaction of the GP Ib-IX-V complex to VWF initiates initial platelet adhesion to vascular subendothelium after vascular injury, platelet activation, thrombosis, and hemostasis. Other known ligands for GPIb-IX-V include α-thrombin, clotting factors XI/XIIa, and high-molecularweight kininogen. | Additional information: Clone REA185 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | GP1BA, BDPLT1, BDPLT3, BSS, CD42b-alpha, DBPLT3, GP1B, GPIbA, VWDP, gpIbα |
Gene, Accession # | Gene ID: 2811 |
Catalog # | 130-100-200 |
Price | $99 |
Order / More Info | CD42b, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Shrimpton, C. N. et al. (2002) Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation. J. Exp. Med. 196: 1057. | Andrews, R. K. et al. (1997) Molecular mechanisms of platelet adhesion and activation. Int. J. Biochem. Cell Biol. 29 (1): 91-105. | Andrews, R. K. et al. (2003) Glycoprotein Ib-IX-V. Int. J. Biochem. Cell Biol. 35 (8): 1170-1174. |