Edit |   |
---|---|
Antigenic Specificity | CD152, Mouse |
Clone | REA984 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 30 µg in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD152 Antibody, anti-mouse, PE, REAfinity™. Clone REA984 recognizes the mouse CD152 antigen, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4), which is a 33 kDa member of the immunoglobin superfamily and is expressed on activated T cells at a low level. CTLA-4 and CD28 have similarities concerning B7 family counter-receptors. While CD28 delivers a co-stimulary signal in T cell activation, CD152 restricts the progression of T cells to an activated state by inhibiting interleukin 2 (IL-2) secretion and cellular proliferation. A large proportion of CTLA-4 is intracellular localized. For a complete detection it may be necessary to assess intracellular staining in addition to surface expression of CD152. | Additional information: Clone REA984 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | CTLA-4, CTLA4, Ly-56 |
Gene, Accession # | Gene ID: 12477 |
Catalog # | 130-116-454 |
Price | $71 |
Order / More Info | CD152, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | June, C. H. et al. (1994) The B7 and CD28 receptor families. Immunol. Today 15 (7): 321-331. | Walunas, T. L. et al. (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1 (5): 405-413. | Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182 (2): 459-465. |