CD87, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD87, Mouse |
| Clone | REA630 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD87 Antibody, anti-mouse, APC, REAfinity™. Clone REA630 recognizes the mouse CD87 antigen, a key molecule involved in invasive migration of angiogenic endothelium, also known as uPAR. CD87 binds uPA (urokinase plasminogen activator) and thus facilitates the catalytic C domain of the uPA to come in close proximity of membranebound plasminogen. uPA is a serine protease, which converts plasminogen into plasmin which in turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2, and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. CD87 is expressed in angiogenic endothelial cells. | Additional information: Clone REA630 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | U-PAR, uPAR |
| Gene, Accession # | Gene ID: 18793 |
| Catalog # | 130-109-856 |
| Price | $88 |
| Order / More Info | CD87, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Miljkovic-Licina, M. et al. (2009) Sushi repeat protein X-linked 2, a novel mediator of angiogenesis. FASEB J. 23 (12): 4105-4116. | Lin, L. et al. (2010) Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J. Biol. Chem. 285 (14): 10982-10992. | Suh, T. T. et al. (1994) The murine urokinase-type plasminogen activator receptor gene. J. Biol. Chem. 269 (42): 25992-25998. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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