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Antigenic Specificity | Ly-49G2, Mouse |
Clone | 4D11 |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2aκ |
Format | phycoerythrin (PE) conjugate |
Size | 30 µg in 1 mL |
Concentration | 1:10 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ly-49G2 Antibody, anti-mouse, PE. The monoclonal antibody 4D11 recognizes Ly-49G2, which is a inhibitory receptor specific for class Ia MHC molecules. Ly-49G2 belongs to the Ly-49 multigene family, which consists of type II transmembrane homodimeric receptors. Inhibitory Ly-49 members such as Ly-49G2 contain immunoreceptor tyrosine-based inhibitory motif (ITIM) 3 in their cytoplasmic tail and transduce signal that prevents the NK cell cytolytic activity upon recognizing ligands such as H-2Ddk. Expression of Ly-49G2 is found on subsets of natural killer (NK) cells, NK-T cells, and on a population of memory CD8+ T cells (in C57BL/6 mice). | |
Immunogen | n/a |
Other Names | Klra7, LGL-1, Ly49G.4, Ly-49G, Ly49g1, Ly-49G2 |
Gene, Accession # | Gene ID: 16638 |
Catalog # | 130-102-332 |
Price | $67 |
Order / More Info | Ly-49G2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Silver, E. T. et al. (2002) Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands. J Immunol 169: 4752-4760. | Barao, I. et al. (2011) Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC. Blood 117: 7032-7041. |