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Antigenic Specificity | CD49d, Human |
Clone | MZ18-24A9 |
Host Species | Mouse |
Reactive Species | human, nonhuman primate |
Isotype | IgG2bκ |
Format | PE-Vio 770 conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD49d Antibody, anti-human, PE-Vio® 770. CD49d, also known as the α4 integrin chain or VLA-4α chain, is a 150 kDa cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with β7 integrin, the resulting α4β7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin to facilitate the rolling of leukocytes along vascular epithelium. In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3-mediated signaling. | CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils. |
Immunogen | n/a |
Other Names | ITGA4, IA4, VLA-4α |
Gene, Accession # | Gene ID: 3676 |
Catalog # | 130-125-244 |
Price | $164 |
Order / More Info | CD49d, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | n/a |