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Antigenic Specificity | CD80, Human |
Clone | 2D10 |
Host Species | Mouse |
Reactive Species | human, nonhuman primate |
Isotype | IgG1κ |
Format | PE-Vio 770 conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD80 Antibody, anti-human, PE-Vio® 770. CD80, also known as B7-1, is a 262 amino acid long 60 kDa molecule and a member of the immunoglobulin superfamily. Together with CD86 (B7-2) it belongs to the B7 family of costimulatory molecules. CD80 is expressed on activated B cells, dendritic cells, and monocytes/ macrophages. The interaction of CD80 with its ligands CD28 and CD152 (CTLA-4) plays a critical role in induction and regulation of immune responses. Binding of CD80 to CD28, which is constitutively expressed on T cells, provides a costimulatory signal and induces T cell proliferation and cytokine production. In contrast, binding to CTLA-4 strongly inhibits proliferation and interleukin 2 (IL-2) secretion by T cells. |
Immunogen | n/a |
Other Names | B7, B7-1, BB1, CD28LG, CD28LG1, LAB7 |
Gene, Accession # | Gene ID: 941 |
Catalog # | 130-126-052 |
Price | $164 |
Order / More Info | CD80, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Krummel, M. F. et al. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182 (2): 459-465. | Linsley, P. S. et al. (1991) Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173 (3): 721-730. |