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Antigenic Specificity | DAP12, Human |
Clone | REA900 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | Vio Bright B515 conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DAP12 Antibody, anti-human, Vio® Bright B515, REAfinity™. Clone REA900 recognizes the human DAP12 antigen, a transmembrane signaling polypeptide which consists of an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. DAP12 interacts with several members of the CD300 molecule-like family, CLECSF5 and Siglec14. The association of DAP12 with triggering receptor expressed on myeloid cells (TREM-1) and myeloid DAP12-associating lectin (MDL-1) plays a role in monocytic activation and inflammatory response. DAP12 is found in several tissues, but also in peripheral blood leukocytes. | Additional information: Clone REA900 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | KARAP, TYROBP |
Gene, Accession # | Gene ID: 7305 |
Catalog # | 130-122-797 |
Price | $430 |
Order / More Info | DAP12, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Tomasello, E. et al. (2000) Association of signal-regulatory proteins beta with KARAP/DAP-12. Eur. J. Immunol. 30 (8): 2147-2156. | Gingras, M. S. et al. (2002) TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. Mol. Immunol. 38 (11): 817-824. |