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Antigenic Specificity | CD49d, Mouse |
Clone | R1-2 |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2bκ |
Format | APC-Vio 770 conjugate |
Size | 9 µg in 300 µL |
Concentration | 1:10 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD49d Antibody, anti-mouse, APC-Vio® 770. The monoclonal antibody R1-2 reacts with mouse CD49d, a 150 kDa Integrin family member, also known as integrin α4 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cell-matrix interaction. CD49d associates non-covalently with the integrin β or β1 (CD29) forming the complex VLA4, which is expressed on peripheral lymphocytes, thymocytes, eosinophils, basophils, mast cells, dendritic cells, and monocytes. VLA4 plays a critical role in adhesion and migration of cells into tissues by binding to its ligand VCAM-1 (CD106). Together with the β7 integrin, CD49d forms the heterodimer LPAM-1, which is a ligand for the mucosal vascular addressin (MAdCAM-1). |
Immunogen | n/a |
Other Names | ITGA4, Itga4B, VLA-4α |
Gene, Accession # | Gene ID: 16401 |
Catalog # | 130-105-191 |
Price | $60 |
Order / More Info | CD49d, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Fogler, W. E. et al. (1996) NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J Immunol 156 (12): 4707-4714. | Vermeulen, M. et al. (1998) Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells. Blood 92 (3): 894-900. | Jia, G. Q. et al. (1999) Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions. Int. Immunol. 11 (1): 1-10. | Berlin, C. et al. (1993) Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74 (1): 185-195. | Chacko, S. M. et al. (1989) Identification of a murine Peyer's patch-specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha. Cell 56 (1): 37-46. |