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Antigenic Specificity | CD357 (GITR), Mouse |
Clone | REA980 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | allophycocyanin (APC) conjugate |
Size | 150 µg in 1 mL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD357 (GITR) Antibody, anti-mouse, APC, REAfinity™. Clone REA980 recognizes the mouse CD357 antigen, also known as glucocorticoid-induced TNF-receptor (GITR) or TNFRSF18. CD357 is a member of the TNF receptor superfamily. It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ regulatory T cells (Tregs). Activation of T cells upregulates CD357 expression. Interaction of CD357 (GTITR) with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. CD357 plays an important role in the function of CD4+CD25+ Tregs. | Additional information: Clone REA980 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | GITR, TNFRSF18, AITR |
Gene, Accession # | Gene ID: 21936 |
Catalog # | 130-116-363 |
Price | $360 |
Order / More Info | CD357 (GITR), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Nocentini, G. et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 94: 6216-6221. | Ronchetti, S. et al. (2002) Role of GITR in activation response of T lymphocytes. Blood 100 (1): 350-352. | Rochetti, S. et al. (2004) GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations. Eur. J. Immunol. 34 (3): 613-622. |