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Antigenic Specificity | CD181 (CXCR1), Human |
Clone | REA958 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | PE-Vio 615 conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD181 (CXCR1) Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA958 recognizes the human CD181 antigen, a multi-pass membrane protein also known as C-X-C chemokine receptor type 1 (CXCR1) or IL-8 receptor A (IL-8RA). CD181 is expressed as homodimer or heterodimer with CD182 (CXCR2) and found on granulocytes, natural killer (NK) cells, a subset of T lymphocytes, mast cells, monocytes, endothelial cells, megakarocytes, and oligodendrocytes. It is one of two high-affinity receptors for interleukin 8 (IL-8), a major mediator of immune and inflammatory responses implicated in many disorders, including tumor growth. IL-8, released in response to inflammatory stimuli, binds to the extracellular part of CD181. The ligand-activated intracellular signaling pathways results in neutrophil migration to the site of inflammation. | Additional information: Clone REA958 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | CXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA |
Gene, Accession # | Gene ID: 3577 |
Catalog # | 130-115-887 |
Price | $335 |
Order / More Info | CD181 (CXCR1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Holmes, W. E. et al. (1991) Structure and functional expression of a human interleukin-8 receptor. Science 253 (5025): 1278. | Cummings, C. J. et al. (1999) Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis. J Immunol 162 (4): 2341-2346. |