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Antigenic Specificity | CD80, Human |
Clone | REA661 |
Host Species | Recombinant Human |
Reactive Species | human, nonhuman primate |
Isotype | IgG1 |
Format | Vio Bright B515 conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD80 Antibody, anti-human, Vio® Bright B515, REAfinity™. Clone REA661 recognizes the human CD80 antigen, also known as B7-1. CD80 is a 262 amino acid long 60 kDa molecule and a member of the immunoglobulin superfamily. Together with CD86 (B7-2) it belongs to the B7 family of costimulatory molecules. CD80 is expressed on activated B cells, dendritic cells, and monocytes/ macrophages. The interaction of CD80 with its ligands CD28 and CD152 (CTLA-4) plays a critical role in induction and regulation of immune responses. Binding of CD80 to CD28, which is constitutively expressed on T cells, provides a costimulatory signal and induces T cell proliferation and cytokine production. In contrast, binding to CTLA-4 strongly inhibits proliferation and IL-2 secretion by T cells. | Additional information: Clone REA661 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | B7, B7-1, BB1 |
Gene, Accession # | Gene ID: 941 |
Catalog # | 130-130-555 |
Price | $500 |
Order / More Info | CD80, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Freeman, G. J. et al. (1989) B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol 143 (8): 2714-2722. | Lanier, L. L. et al. (1995) CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J Immunol 154 (1): 97-105. | Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182 (2): 459-465. | Linsley, P. S. et al. (1993) The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11: 191-212. |