CD98, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD98, Human |
| Clone | REA387 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | APC-Vio 770 conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD98 Antibody, anti-human, APC-Vio® 770, REAfinity™. Clone REA387 recognizes the human CD98 antigen, a single-pass type II membrane glycoprotein. CD98 is broadly expressed on non-hematopoietic cells and also on peripheral blood lymphocytes, monocytes, and granulocytes. The CD98 heterodimer consists of a 80-85 kDa heavy chain (CD98hc, also known as 4F2 antigen heavy chain or FRP-1) that is disulfide-linked with a multi-pass light chain of 40 kDa. The heavy chain binds to the cytoplasmic tails of integrin-β chains and mediates adhesive signals that control cell spreading, survival, and growth. The light chain functions in amino acid transport. Some of the light chains have broad specificity, but the large neutral amino acid transporters LAT-1 and LAT-2 have preference for importing certain essential amino acids, particularly leucine, isoleucine, and arginine (LAT-1), in exchange for glutamine. Through its nutrient function, CD98 can contribute to the survival and growth of many cell types. CD98hc functions in amplifying integrin signaling and in the transport of amino acids. Both of these functions can contribute to cell survival and proliferation. | Additional information: Clone REA387 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | SLC3A2, SLC7A5, 4F2hc |
| Gene, Accession # | Gene ID: 6520, 8140 |
| Catalog # | 130-105-664 |
| Price | $360 |
| Order / More Info | CD98, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Quackenbush, E. et al. (1987) Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth. Proc. Natl. Acad. Sci. U.S.A. 84 (18): 6526-6530. | Cantor, J. M. et al. (2012) CD98 at the crossroads of adaptive immunity and cancer. J. Cell. Sci. 125 (6): 1373-1382. | Kanai, Y. et al. (1998) Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J. Biol. Chem. 273 (37): 23629-23632. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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