CD275 (B7-H2), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD275 (B7-H2), Mouse |
| Clone | REA990 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD275 (B7-H2) Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA990 recognises the mouse CD275 antigen, which is also known as B7-H2 or ICOSL. CD275 is a type I membrane protein and belongs to the Ig superfamily, B7 family of co-stimulatory molecules. Expression of CD275 is found on antigen presenting cells such as B cells, dendritic cells, and monocytes. CD275 co-stimulates T cells upon binding to inducible T cell co-stimulator (ICOS), which is expressed on activated T cells. In mouse, CD275 binds only ICOS, whereas in humans it can interact with other T cell co-stimulatory molecules, CD28 and CTLA-4. To appropriately regulate the activation of immune response, the ICOS-CD275 interaction can also lead to downregulation of CD275 expression which allows prevention of hyperreaction of T cells. | Additional information: Clone REA990 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50 |
| Gene, Accession # | Gene ID: 50723 |
| Catalog # | 130-116-448 |
| Price | $156 |
| Order / More Info | CD275 (B7-H2), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Watanabe, M. et al. (2008) Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. J Immunol 180: 5222-5234. | Yao, S. et al. (2011) B7-H2 is a costimulatory ligand for CD28 in human. Immunity 34 (5): 729-740. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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