DLL4, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | DLL4, Human |
| Clone | REA1065 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 615 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | DLL4 Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA1065 recognizes the human delta-like4 (DLL4) antigen, which is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Notch signaling controls cell fate decisions and is involved in multiple developmental processes. Notch ligands are categorized into two subfamilies: the Jagged and the Delta ligand family. In mammals, five ligands (DLL 1, 3, and 4, Jagged 1 and 2) have been identified. DLL4 is highly expressed within vascular endothelial cells, thymic epithelial cells, and dendritic cell subsets and plays an important role for vascular development and homeostasis and thymic as well as peripheral T cell differentiation. | Additional information: Clone REA1065 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | hdelta2, Delta-like4, Delta-like protein 4 |
| Gene, Accession # | Gene ID: 54567 |
| Catalog # | 130-118-229 |
| Price | $350 |
| Order / More Info | DLL4, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Noguera-Troise, I. et al. (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444 (7122): 1032-1037. | Ridgeway, J. et al. (2006) Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444 (7122): 1083-1087. | Koch, U. et al. (2008) Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J. Exp. Med. 205 (11): 2515-2523. | Hozumi, K. et al. (2008) Delta-like 4 is indispensable in thymic environment specific for T cell development. J. Exp. Med. 205 (11): 2507-2513. | Radtke, F. et al. (2010) Notch signaling in the immune system. Immunity 32: 14-27. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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