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Antigenic Specificity | CD197 (CCR7), Human |
Clone | REA108 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD197 (CCR7) Antibody, anti-human, PE, REAfinity™. REA108 recognizes human CD197 which is a chemokine receptor with a C-C motif that mediates homing of T cells to secondary lymphoid organs via high endothelial venules (HEV) and is also known as CCR7. For example, naive T cells migrate very efficiently through lymph nodes using the adhesion molecules L-selectin, CD62L, and CCR7. Ligands for CCR7, e.g. CCL19, are expressed by the HEV of secondary lymphoid organs, by parenchymal cells within T cell zones of lymph nodes, and by endothelial cells at the openings of lymphatic vessels within peripheral tissues. Expression of CCR7 and the CD45RA isoform distinguishes three subsets of T cells: naive T cells (CCR7+CD45RA+), central memory T cells (CCR7+ CD45RA-), and effector memory T cells (CCR7- CD45RA-). | Additional information: Clone REA108 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | CCR7, BLR-2, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI-1 |
Gene, Accession # | Gene ID: 1236 |
Catalog # | 130-120-463 |
Price | $310 |
Order / More Info | CD197 (CCR7), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Bacher, P. et al. (2014) Identification of immunogenic antigens from Aspergillus fumigatus by direct multi parameter characterization of specific conventional and regulatory CD4+ T cells. J Immunol 193: 3332-3343. | Sallusto, F. et al. (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708-712. | Baldan, W. et al. (2015) Efficient and reproducible generation of tumour-infiltrating lymphocytes for renal cell carcinoma. Br. J. Cancer 112 (9): 1510-1518. | Frascaroli, G. et al. (2018) Human macrophages escape inhibition of major histocompatibility complex-dependent antigen presentation by Cytomegalovirus and drive proliferation and activation of memory CD4+ and CD8+ T cells. Front Immunol 9: . | Tilly, G. et al. (2017) IL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients. Front Immunol 8: . | Alvarez-Fernandez, C. et al. (2016) A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy. J. Transl. Med. 14: 214. | Chang, Z. L. et al. (2015) Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors. J. Transl. Med. 13: 161. |