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Antigenic Specificity | CD197 (CCR7), Mouse |
Clone | 4B12 |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2aκ |
Format | phycoerythrin (PE) conjugate |
Size | 30 µg in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD197 (CCR7) Antibody, anti-mouse, PE. Clone 4B12 reacts with CD197 (CCR7), a chemokine receptor for chemokines CCL19 and CCL21. CD197, like other chemokine receptors, has seven-transmembrane spanning domains and signals via G proteins. Expression of CD197 is found on semi-mature and mature dendritic cells (DCs), naive B and T cells, regulatory T (Treg) cells, a subpopulation of T cells called central memory T cells, and non-immune malignant cells. CD197 is involved in regulating homing of immune cells, immunity to pathogens, immune tolerance, development and function of Tregs, and manifestation of autoimmunity. |
Immunogen | n/a |
Other Names | CCR7, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI1, Ebi1h |
Gene, Accession # | Gene ID: 12775 |
Catalog # | 130-126-035 |
Price | $65 |
Order / More Info | CD197 (CCR7), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Bjorkdahl, O. et al. (2003) Characterization of CC-chemokine receptor 7 expression on murine T cells in lymphoid tissues. Immunology 110 (2): 170-179. | Forster, R. et al. (2008) CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 8 (5): 362-371. |