LAP (TGF-β1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | LAP (TGF-β1), Human |
| Clone | REA1214 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | LAP (TGF-β1) Antibody, anti-human, APC, REAfinity™. Clone REA1214 recognizes the N-terminal latency-associated peptide (LAP) of the transforming growth factor β1 (TGF-β1) dimer. TGF-β1 belongs to a family of homologous, disulfide-linked, homodimeric proteins. These highly pleiotropic cytokines inhibit proliferation of most cells, but can promote the growth of mesenchymal cells and enhance extracellular matrix formation. The pivotal function of TGF-β1 in the immune system is to mediate immunosuppression and maintain tolerance by regulating lymphocyte proliferation, differentiation, and survival. TGF-β1 is produced by many cell types, but is reported to be most abundant in mammalian platelets and bone. It is secreted predominantly as an inactive latent complex. After proteolytical processing of the TGF-β1 precursor, the resulting N-terminal latency-associated peptide (LAP) remains non-covalently associated with the TGF-β1 dimer. Mature and biologically active TGF-β1 can be released from the complex by action of proteases and/or conformational changes. LAP-TGF-β1 was described to be expressed on the cell surface of activated human regulatory T cells. | Additional information: Clone REA1214 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | TGFB1, CED, DPD1 |
| Gene, Accession # | Gene ID: 7040 |
| Catalog # | 130-123-410 |
| Price | $325 |
| Order / More Info | LAP (TGF-β1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Tran, D. Q. et al. (2009) Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FoxP3+ regulatory T cells allows for their purification from expansion cultures. Blood 113: 5125-5133. | Tran, D. Q. et al. (2009) GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 106: 13445-13450. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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