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Antigenic Specificity | TIM-3, Human |
Clone | F38-2E2 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1κ |
Format | biotin conjugate |
Size | 100 tests in 1 mL |
Concentration | 1:11 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TIM-3 Antibody, anti-human, Biotin. The monoclonal antibody F38-2E2 recognizes human cell surface molecule TIM-3, which is expressed on activated T cells, especially T?1 cells, monocytes, macrophages, and dendritic cells. TIM-3 has been proposed to inhibit T?1-mediated immune responses and regulates T?1 and T?17 cytokine secretion. The interaction of TIM-3 and its ligand galectin-9 induces apoptosis of T?1 cells. | |
Immunogen | n/a |
Other Names | HAVCR2, CD366, HAVcr-2, KIM-3, TIMD-3 |
Gene, Accession # | Gene ID: 84868 |
Catalog # | 130-098-945 |
Price | $264 |
Order / More Info | TIM-3, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Monney, L. et al. (2002) T?1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541. | Zhu, C. et al. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6 (12): 1245-1252. | Hastings, W. D. et al. (2009) TIM-3 is expressed on activated human CD4+ T cells and regulates T?1 and T?17 cytokines. Eur. J. Immunol. 39 (9): 2492-2501. | Hirsch, S. et al. (1983) Polymorphic expression of a neutrophil differentiation antigen revealed by monoclonal antibody 7/4. Immunogenetics 18 (3): 229-239. |