CD86, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD86, Human |
| Clone | REA968 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD86 Antibody, anti-human, FITC, REAfinity™. Clone REA968 recognizes the human CD86 antigen, also known as B7-2 or B70, which is an 80 kDa molecule and a member of the immunoglobulin superfamily. Together with CD80 (B7-1) it belongs to the B7 family of co-stimulatory molecules. CD86 is expressed on activated B and T cells, dendritic cells, and monocytes/macrophages. The interaction of CD86 with its ligands CD28 and CD152 (CTLA- 4) plays a critical role in induction and regulation of immune responses, e.g., cross-talk between T and B cells, T cell costimulation, or immunoglobulin class-switching. Binding of CD86 to CD28 on T cells results in transduction of costimulatory signals for activation or proliferation of T cells or cytokine production. | Additional information: Clone REA968 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | B7-2, B70, CD28LG2, LAB72 |
| Gene, Accession # | Gene ID: 942 |
| Catalog # | 130-116-159 |
| Price | $270 |
| Order / More Info | CD86, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Azuma, M. et al. (1993) B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366 (6450): 76-79. | Engel, P. et al. (1994) The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. Blood 84 (5): 1402-1407. | Lanier, L. L. et al. (1995) CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J Immunol 154 (1): 97-105. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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