CD324 (E-Cadherin), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD324 (E-Cadherin), Human |
| Clone | REA811 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD324 (E-Cadherin) Antibody, anti-human, APC, REAfinity™. Clone REA811 recognizes CD324, also known as E-cadherin or cadherin-1, which is a calcium-dependent cell adhesion protein found in adherence junctions of epithelial cells, e.g., in colon, uterus, liver, keratinocytes, etc. E-cadherin also serves as a ligand for integrin α-E/β-7. The epitope is expressed by a variety of carcinoma-derived cell lines such as MCF-7, HT-29, T-47D, NTERA-2, and 2102Ep. Loss of E-cadherin is thought to enable metastasis by disrupting intercellular contacts - an early step in metastatic dissemination. Furthermore, E-cadherin is a marker of undifferentiated embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. For these cells, E-cadherin plays a major role in conveying cell survival signals. | Additional information: Clone REA811 displays negligible binding to Fc receptors |
| Immunogen | n/a |
| Other Names | CDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin, Cadherin-1 |
| Gene, Accession # | Gene ID: 999 |
| Catalog # | 130-111-993 |
| Price | $142 |
| Order / More Info | CD324 (E-Cadherin), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Onder, T. T. et al. (2008) Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 68: 3645-3654. | Eastham, A. M. et al. (2007) Epithelial-mesenchymal transition events during human embryonic stem cell differentiation. Cancer Res. 67: 11254-11262. | Higgins, J. M. et al. (1998) Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin. J. Cell Biol. 140: 197-210. | Li, Z. et al. (2010) Spatially resolved quantification of E-cadherin on target hES cells. J. Phys. Chem. B 114: 2894-2900. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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