O4, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityO4, Human/Mouse/Rat
CloneREA576
Host SpeciesRecombinant Human
Reactive Specieshuman, mouse, rat
IsotypeIgG1
FormatVio Bright B515 conjugate
Size100 tests in 200 µL
Concentration1:50
ApplicationsIntracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence
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DescriptionO4 Antibody, anti-human/mouse/rat, Vio® Bright B515, REAfinity™. Clone REA576 recognizes the human, mouse, and rat O4 antigen, a marker for oligodendrocytes, which are a type of glial cells. Their function is to provide a supporting role for neurons. During oligodendrocyte development, late A2B5+ oligodendrocyte progenitors start to express O4. As the cells differentiate, A2B5 expression ceases, whereas O4 expression persists. More mature cells start to synthesize galactocerebroside, MBP, PLP, MOG, and O1. O4 expression is found on Schwann cells in the peripheral nervous system. | Additional information: Clone REA576 displays negligible binding to Fc receptors.
Immunogenn/a
Other NamesOligodendrocyte marker O4
Gene, Accession #n/a
Catalog #130-120-016
Price$470
Order / More InfoO4, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesSommer, I. and Schachner, M. (1981) Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: an immunocytological study in the central nervous system. Dev. Biol. 83: 311-327. | Bansal, R. et al. (1989) Multiple and novel specificities of monoclonal antibodies O1, O4, and R-mAb used in the analysis of oligodendrocyte development. J. Neurosci. Res. 24 (4): 548-557. | Zhang, S. C. (2001) Defining glial cells during CNS development. Nat. Rev. Neurosci. 2: 840-843.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

macs@miltenyibiotec.de

https://www.miltenyibiotec.com

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