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Antigenic Specificity | CD28, Human |
Clone | REA612 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | Vio Bright B515 conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD28 Antibody, anti-human, Vio® Bright B515, REAfinity™. Clone REA612 recognizes the human CD28 antigen, a type I transmembrane protein, which is highly expressed on CD3+ thymocytes, most peripheral thymocytes, and plasma cells but not in less mature B cells. Binding of CD28 to its ligands CD80 or CD86 costimulates T cell effector function and T cell-dependent antibody production in vitro and in vivo. In the presence of antibodies directed against CD2 and CD3, CD28 antibodies stimulate T cell proliferation and cytokine production. | Additional information: Clone REA612 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | T44, Tp44 |
Gene, Accession # | Gene ID: 940 |
Catalog # | 130-126-890 |
Price | $500 |
Order / More Info | CD28, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Kozbor D. J. et al. (1987) Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells. J Immunol 138 (12): 4128-4132. | Bahlis, N. J. et al. (2007) CD28-mediated regulation of multiple myeloma cell proliferation and survival. Blood 109 (11): 5002-5010. | Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182 (2): 459-465. | Freeman, G. J. et al. (1993) Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262 (5135): 909-911. | Linsley, P. S. et al. (1993) The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11: 191-212. | June, C. H. et al. (1990) Role of the CD28 receptor in T-cell activation. Immunol. Today 11 (6): 211-216. |