CD229 (Ly-9), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD229 (Ly-9), Human
CloneHly9.1.25
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1κ
Formatphycoerythrin (PE) conjugate
Size30 tests in 300 µL
Concentration1:11
ApplicationsFlow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
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DescriptionCD229 (Ly-9) Antibody, anti-human, PE. Clone Hly9.1.25 reacts with CD229, a type I transmembrane glycoprotein belonging to the CD150 subfamily of leukocyte receptors of the Ig superfamily. CD229 has four extracellular Ig domains and a cytoplasmic domain containing two copies of the tyrosine-based motif (T-I/V-Y-x-x-V/I). Via this unique motif, CD229 interacts with SH2-binding phosphatases and the adapter molecules SAP, EAT-2, and Grb2. Expression of CD229 is found on T cells, B cells, NK cells, and thymocytes. CD229 interacts homophilically via its N-terminal V-like domain and is involved in enhancing T cell activation and T?2 polarization.
Immunogenn/a
Other NamesLy-9, SLAMF3, hly9, mLY9
Gene, Accession #Gene ID: 4063
Catalog #130-100-112
Price$110
Order / More InfoCD229 (Ly-9), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesMartin, M. et al. (2005) Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229. J Immunol 174: 5977-5986. | Romero, X. et al. (2005) CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. J Immunol 174 (11): 7033-7042. | Romero, X. et al. (2004) Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). Tissue Antigens 64 (2): 132-144.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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