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Antigenic Specificity | IL-12 (p70), Human |
Clone | REA123 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | allophycocyanin (APC) conjugate |
Size | 30 tests in 300 µL |
Concentration | 1:10 |
Applications | Intracellular flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | IL-12 (p70) Antibody, anti-human, APC, REAfinity™. Interleukin-12 (IL-12) is a 70-75 kDa heterodimeric cytokine composed of a 40 kDa heavy chain and a 35 kDa light chain. It is produced mainly by monocytes and macrophages and by dendritic cells, primarily in response to stimulation with bacterial or viral antigens. IL-12 has also been described to be produced by non-hematopoietic cells such as keratinocytes and epidermoid carcinomas. IL-12 displays various effects on both NK and T cells, playing an essential role in the interaction between innate and adaptive immunity. It induces the production of IFN-γ alone or in synergy with IL-2, acts as a co-stimulator of both NK and T cell proliferation, and enhances cytolytic activity of both cell types. Moreover, IL-12 promotes the development of T helper 1 (T?1)-specific immune responses by promoting the differentiation of CD4+ cells towards a T?1 phenotype while inhibiting the production of T?2 cells. Clone REA123 reacts with the biologically active form of human IL-12 p70 heterodimer, but not with the p40 monomer or homodimer. | Additional information: Clone REA123 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | IL12A, CLMF, NFSK, P35, CLMF, IL12B, IMD28, IMD29, NKSF |
Gene, Accession # | Gene ID: 3592, 3593 |
Catalog # | 130-103-738 |
Price | $142 |
Order / More Info | IL-12 (p70), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | D?Andrea, A. et al. (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176: 1387-1398. | Gubler, U. et al. (1991) Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4143-4147. | Trinchieri, G. et al. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3 (2): 133-146. |