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Antigenic Specificity | CD28, Rat |
Clone | REA206 |
Host Species | Recombinant Human |
Reactive Species | rat |
Isotype | IgG1 |
Format | biotin conjugate |
Size | 30 µg in 1 mL |
Concentration | 1:10 |
Applications | Mass cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD28 Antibody, anti-rat, Biotin, REAfinity™. Clone REA206 recognizes rat CD28, a 44 kDa glycoprotein also known as Tp44. CD28 is a homodimeric type I transmembrane protein of the Ig receptor superfamily, composed of disulfide-linked subunits. It is a costimulatory molecule which is expressed on most thymocytes, CD4+ and CD8+ T cells, and NK cells. Expression of CD28 is down-regulated at late stages of terminal effector T cell differentiation. Ligation of CD28 with CD80 (B7-1) and CD86 (B7-2) provides a costimulatory signal for T cell activation. | Additional information: Clone REA206 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | CD28RNA |
Gene, Accession # | Gene ID: 25660 |
Catalog # | 130-101-976 |
Price | $57 |
Order / More Info | CD28, Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Clark, G. J. et al. (1992) Identification of a cDNA encoding the rat CD28 homologue. Immunogenetics 35 (1): 54-57. | Guo, L. et al. (2003) Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation. Transpl Immunol. 12 (1): 41-48. |