CD195 (CCR5), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD195 (CCR5), Mouse |
| Clone | REA354 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | APC-Vio 770 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD195 (CCR5) Antibody, anti-mouse, APC-Vio® 770, REAfinity™. Clone REA354 recognizes the mouse CD195 antigen, a multi-pass membrane protein which is also known as C-C chemokine receptor type 5 (CCR5). CD195 belongs to the G-protein coupled receptor 1 family and is predominantly expressed on T cells, macrophages, dendritic cells, and microglia. It is a receptor for a number of inflammatory CC-chemokines including MIP-1-α, MIP-1-β, and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. CD195 is involved in the chemotaxis of leucocytes to inflammation sites and plays an important role in the recruitment of macrophages, T cells, and monocytes in inflammation. Additionally, CCR5 may have an indirect effect on cancer progression by controlling the antitumor immune response, since it has been demonstrated that its expression could promote tumor growth and contribute to tumor metastasis. | Additional information: Clone REA354 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CCR5, AM4-7, CD195, CMKBR5 |
| Gene, Accession # | Gene ID: 12774 |
| Catalog # | 130-120-168 |
| Price | $160 |
| Order / More Info | CD195 (CCR5), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Barashi, N. et al. (2013) Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology 58 (3): 1021-1030. | Meyer, A. et al. (1996) Cloning and characterization of a novel murine macrophage inflammatory protein-1 alpha receptor. J. Biol. Chem. 271 (24): 14445-14451. | Doranz, B. J. et al. (1997) Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1. J. Virol. 71 (9): 6305-6314. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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