STAT6 pY641, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | STAT6 pY641, Human |
| Clone | REA413 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio B515 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | STAT6 pY641 Antibody, anti-human, Vio® B515, REAfinity™. Clone REA413 recognizes the human signal transducer and activator of transcription 6 (STAT6) antigen phosphorylated at tyrosine 641 (pY641). STAT proteins transmit signals from a receptor complex to the nucleus and activate gene expression. The seven members of the STAT family are predominantly activated by growth factors and cytokines. STAT6 expression is found in many tissues. It is activated by two cytokines, IL-4 and IL-13, and plays a predominant role in the immune system. Once these cytokines bind to their cognate receptors, the associated janus kinases are activated and phosphorylate conserved tyrosine residues on the receptor. Once phosphorylated, STAT6 forms homodimers and translocates to the nucleus. In the nucleus, STAT6 has the ability to bind directly to DNA via a DNA-binding domain and is able to regulate transcription. IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis. | Additional information: Clone REA413 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | IL-4 Stat, STAT6B, STAT6C |
| Gene, Accession # | Gene ID: 6778 |
| Catalog # | 130-130-933 |
| Price | $158 |
| Order / More Info | STAT6 pY641, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Hou, J. et al. (1994) An interleukin-4-induced transcription factor: IL-4 Stat. Science 265 (5179): 1701-1706. | Quelle, F. W. et al. (1995) Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell. Biol. 15 (6): 3336-3343. | Zhou, L. et al. (2012) STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells. Bioorg. Med. Chem. 20 (2): 750-758. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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