Edit |   |
---|---|
Antigenic Specificity | Human IL-31 |
Clone | [SB118b1] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Reacts with native and recombinant human IL-311. Interleukin-31 (IL-31) is a 24kD alpha-helical protein and a member of the IL-6 family of cytokines that is preferentially expressed by CD4+ T cells2. This cytokine elicits its response by binding to a heterodimeric complex consisting of a gp130-like receptor chain and the oncostatin M receptor subunit. On target cells which include a broad range of immune and non-immune cells, IL-31 binding can induce activation of the Jak/STAT, AKT and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles that include regulating hematopoiesis and immune response3,4. Over-expression has been linked chronic inflammatory states such as dermati |
Immunogen | Immunogen: Recombinant human IL-31. Characterization: To ensure acceptable performance, each batch of product is tested by ELISA to conform to characteristics of a standard reference reagent. |
Other Names | [Mouse Human Interleukin-31 (IL-31)], [IL31; IL31; IL-31; IL-31] |
Gene, Accession # | Gene ID: 386653, NCBI: NP_001014358.1, UniProt: Q6EBC2 |
Catalog # | MBS670218 |
Price | $340 |
Order / More Info | Human IL-31 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1) Zhang, Q. et al. (2008). Cyto. Grow. Rev. 19:347-56.3) Broxmeyer, H.E. et al. (2007). Exp. Hematol. 35:78-86.4) Perrigoue, J.G. et al. (2007). J. Exp. Med. 204:481-7.5) Sonkoly, E. et al. (2006). J. All. Clin. Immunol. 117:411-7.6) Dillon, S.R. et al. (2004). Nat. Immunol. 5:752-60.7) Dambacher, J. et al. (2007). Gut. 56:1257-65. |