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Antigenic Specificity | Cathepsin D |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 500 ug/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitr |
Immunogen | Immunogen: Cathepsin D antibody was raised in Rabbit using synthetic peptide surrounding amino acid 140 of mouse cathepsins D as the immunogen. |
Other Names | [Rabbit Cathepsin D; Cathepsin D; Cathepsin D; CPSD; CLN10; MGC2311; CTSD] |
Gene, Accession # | [CPSD], Gene ID: 1509, UniProt: P07339 |
Catalog # | MBS5311212 |
Price | $445 |
Order / More Info | Cathepsin D Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |