NGFR Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | NGFR |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The p75 neurotrophin receptor (p75NTR), a member of the TNF receptor superfamily, is distinguished by multiple cysteine-rich ligandbinding domains, a single transmembrane sequence and a noncatalytic cytoplasmic domain (1). p75NTR displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, p75NTR recognizes neurotrophins and transmits trophic signals into the cell. Both p75NTR and TrkA are required to activate PI3K-Akt signaling, while TrkA can individually activate the MAP kinase pathway. In contrast, p75NTR, possibly through JNK, ensures appropriate apoptosis of injured neurons and improperly targeted neonatal neurons (2).The p75NTR protein undergoes sequential cleavage similar t |
| Immunogen | Immunogen: A synthetic -peptide of human NGFR |
| Other Names | [NGFR; CD271; Gp-80LNGFR; TNFRSF16; p75(NTR); p75NTR], [NGFR; NGFR; CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; TNFRSF16; NGF receptor] |
| Gene, Accession # | Gene ID: 4804, NCBI: NP_002498.1, UniProt: P08138 |
| Catalog # | MBS125019 |
| Price | $275, $430 |
| Order / More Info | NGFR Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Chao, M.V. (2003) Nat. Rev. Neurosci. 4, 299-309. 2. Nykjaer, A. et al. (2005) Curr. Opin. Neurobiol. 15, 49-57. 3. Kanning, K.C. et al. (2003) J. Neurosci. 23, 5425-5436. 4. Jung, K.M. et al. (2003) J. Biol. Chem. 278, 42161-42169. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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