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Antigenic Specificity | Mouse IL-6 receptor |
Clone | [14F33] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2 |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) - Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody detects mouse IL-6R in Western blotting. The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6 R) and a signal-transducing component of 130 kDa (gp 130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. A soluble form of the IL-6 R alpha has been found in the urine of healthy adult humans. This soluble receptor apparently arises from proteolytic cleavage of membrane-bound IL-6 R alpha. No naturally-occurring mRNA encoding a truncated form of the IL-6 R alpha has been reported. Soluble forms of human a |
Immunogen | Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of IL-6R extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography. |
Other Names | [mouse Interleukin-6 Receptor (#14F33)], [Il6ra; Il6ra; Il6r; CD126; IL-6R; Il6r; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA] |
Gene, Accession # | [IL-6 receptor], Gene ID: 16194, NCBI: NP_034689.2, UniProt: P22272 |
Catalog # | MBS690088 |
Price | $490 |
Order / More Info | Mouse IL-6 receptor Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |